People

Rinri Therapeutics is assembling an exceptional team, with experience from all sectors of biotech and pharma industries. The Board, Management Team and Scientific Founder will be responsible for taking all aspects of this ground-breaking research to the clinic.

Nick Higgins – Independent Chair

Nick Higgins – Independent Chair

Nick is an experienced life sciences executive with significant business and corporate development achievements. He has over 35 years in the life sciences industry with extensive knowledge of UK and US markets in both private and public sectors. With a special interest in advanced therapies he has worked actively in the field of cell and gene therapies for many years.

Nick is a Director of Lizard BioConsulting, an independent consultancy specialising in business development for life science companies, which he founded in 2013. He is also Deputy Chairman of the Cell & Gene Therapy Catapult and Chairman of Avvinity Therapeutics, a private company focused on immuno-oncology.

Dr. Erica Whittaker – Investor Director

Dr. Erica Whittaker – Investor Director and Chair

Erica is Head of UCB Ventures, a strategic corporate venture fund. She also serves on the Boards of StrideBio (Durham, North Carolina) and Ally Therapeutics (Cambridge, Massachusetts). She joined UCB in 2010 as VP Strategy & Partnering, New Medicines (discovery to clinical proof of concept), developing and leading the UCB-Harvard Research Alliance. In 2012, she joined the internal strategy team shaping UCB’s current Patient Value Strategy. As Head of Market Access EMEA 2013-2017, Erica was instrumental in developing regional patient access and pricing strategies and was Chair of the Healthcare Systems Working Group of the European Federation of Pharmaceutical Industries Association (EFPIA). Prior to UCB, Erica spent 10 years as a top-ranked biotechnology equity analyst for Merrill Lynch in London, where she conducted analyses for publicly listed European biotechnology and mid-cap pharmaceutical companies. Erica attended Brown University (Rhode Island, USA) receiving BA degrees in Biology and Comparative Literature. She moved to the UK on a Marshall Scholarship obtaining a Ph.D. in Molecular Biology from the University of Edinburgh and an MBA from Heriot-Watt University Business School in Edinburgh.

Frank Kalkbrenner – Investor Director

Frank KalkbrennerFrank is the Global Head of the Boehringer Ingelheim Venture Fund. He served as board member of STAT Diagnostica (acquired by Qiagen in 2018), Hookipa Biotech (IPO at NASDAQ in 2019) and Amal Therapeutics (acquired by Boehringer Ingelheim in 2019). Currently, he is on the Boards of Rinri Therapeutics, T3 Pharma, eTheRNA, Aelin Therapeutics, Acousia Therapeutics, and Brainomix. A physician by training, with a Ph.D. in Pharmacology and a Pharmacology and Toxicology specialitism. He spent more than 10 years in academic research in the Max-Planck-Institute for Molecular Genetics and in the Institute of Pharmacology of the Freie Universität in Berlin. He began his industrial career at Schering AG and moved in 1999 to Boehringer Ingelheim joining Pulmonary Research. In 2005, he took over the responsibility for the Licensing Department. In this function, he was responsible for the licensing activities of the German Boehringer Ingelheim organisation in various indication areas. He also built up the Biological Research unit at the German Research site in Biberach. Shortly after its initiation in 2010, Frank joined the Boehringer Ingelheim Venture Fund.

Dr. Claire Brown – Investor Director

Dr. Claire Brown – Investor DirectorClaire currently leads BioCity’s investment activity making seed-stage investments into early life Science and healthcare companies. The company make off-balance-sheet investments as well as management of a dedicated life science seed fund, Alderley Park Ventures Ltd. Since joining in 2015 Claire has led the majority of the investments in the Company’s broad portfolio spanning therapeutic platforms to medical devices and industrial Biotech and currently serves on the boards of a number of portfolio companies, including Fast BioPharma, Metalinear, Kinomica, and Rinri Therapeutics Ltd. Prior to joining BioCity, Claire held senior R&D leadership and strategic business development roles in global biopharmaceutical companies, in the USA and UK (UCB, Genzyme and AstraZeneca) latterly working alongside AstraZeneca corporate VC group MedIVentures. Claire received her BSc. (Hons.) and Ph.D. from Glasgow University and holds an MBA and is certified in investment management.

Ross McMaster – Investor Director

Ross McMaster – Investor DirectorRoss joined Sheffield University Enterprise Ltd. (SUEL) in 2003 having started his career in both local and national chartered accountancy practices, where he gained extensive knowledge in all areas of accountancy, taxation, and audit. A Fellow of the Association of Chartered Certified Accountants with a degree in Accounting and Business, Ross specialises in the provision of management accounting services, strategic and business planning, financial forecasting and statutory accounts preparation for SME companies. During his time at SUEL Ross has been involved in a variety of fundraising transactions for private limited companies. He also provides corporate governance guidance whilst holding the position of a company secretary to a number of companies spun out from the University of Sheffield.

Professor Marcelo Rivolta – Founder Director

Professor Marcelo Rivolta – Founder DirectorMarcelo is a globally recognised thought leader in the area of sensory stem cells authoring over 40 papers in the field, including publishing in Nature. The Rivolta laboratory is dedicated to studying the biology and behaviour of auditory stem cells and to explore their potential to regenerate the damaged inner ear. His academic group has made key advances in developing stem cell technologies into a potentially viable therapy establishing that pluripotent stem cell-derived progenitors can repair the damaged cochlea. His program of research has been supported by the MRC, the UK Regenerative Medicine Platform, the EU, the Wellcome Trust, charities like Action on Hearing Loss and he has led several UK and international collaborations with industry and academia. Marcelo qualified in Medicine and Surgery in 1989 at the National University of Cordoba in Argentina and did his Ph.D. work at the National Institute on Deafness and other Communication Disorders in Maryland, USA. He joined the University of Sheffield in 2001 and since 2013 has been Professor of Sensory Stem Cell Biology.

Dr. Natalie Mount – Non Executive Director

Dr. Natalie Mount – Non Executive Director

Natalie is currently the CEO of Adaptate Biotherapeutics Ltd. focused on developing therapeutic antibodies to drug targets to modulate the activity of gamma delta T cells. Previously, Natalie was Chief Scientific Officer of GammaDelta Therapeutics Ltd. which targeted gamma delta T-cell therapies for use in immunotherapy and was one of the founding team at the Cell and Gene Therapy Catapult serving as its Chief Clinical Officer advising academics and small companies developing advanced therapies. Natalie’s prior experience also includes 16 years at Pfizer, leading development activities across various therapeutic areas, including cell-based therapies in the Regenerative Medicine Unit. Natalie has a first-class degree in Natural Sciences from the University of Cambridge and a Ph.D. from University College, London.

Dr. Simon Chandler – CEO

Dr. Simon Chandler – CEOSimon has deep sector knowledge and in-depth experience of the biotech sector and a strong understanding of the advanced therapeutics landscape having spent most of his career within the blue-chip companies in the biotechnology and pharmaceutical industries. Simon joins Rinri Therapeutics from IP Group plc. the specialist early-stage technology venture capital firm where he worked to identify transformative, world-leading investment opportunities from partner University IP portfolios and to then work in tandem with founder teams to build exciting early-stage spin-out technology companies. This included broad exposure to the life science market across AI-diagnostics, medical devices, oesteogenesis, synthetic biology and anti-virals. He was attracted to Rinri by the high calibre nature of the research findings with early but compelling preclinical data showing dramatic restoration of hearing in ontological disease models that clearly demonstrated the potential for the technology to make a real-world impact on patients and healthcare systems. This all made Rinri an exciting prospect to build a pioneering early-stage biotechnology company. Simon received his BSc. (Hons.) from Leeds University and holds a Ph.D. in Molecular Biology and Biochemistry from the University of York and holds CIM qualifications.

Professor Marcelo Rivolta – CSO

Professor Marcelo Rivolta – CSOMarcelo is a globally recognised thought leader in the area of sensory stem cells authoring over 40 papers in the field, including publishing in Nature. The Rivolta laboratory is dedicated to studying the biology and behaviour of auditory stem cells and to explore their potential to regenerate the damaged inner ear. His academic group has made key advances in developing stem cell technologies into a potentially viable therapy establishing that pluripotent stem cell-derived progenitors can repair the damaged cochlea. His program of research has been supported by the MRC, the UK Regenerative Medicine Platform, the EU, the Wellcome Trust, charities like Action on Hearing Loss and he has led several UK and international collaborations with industry and academia. Marcelo qualified in Medicine and Surgery in 1989 at the National University of Cordoba in Argentina and did his Ph.D. work at the National Institute on Deafness and other Communication Disorders in Maryland, USA. He joined the University of Sheffield in 2001 and since 2013 has been Professor of Sensory Stem Cell Biology.

Dr. Terri Gaskell – CTO

Dr. Terri Gaskell – CTOTerri has over 20 years of life sciences R&D experience in both academic and industry roles with a focus on the development and translation of cell- and gene-based therapies. Terri joins from the Cell and Gene Therapy Catapult where she has worked for over seven years on the translation of a broad range of candidate therapies, including stem cell derived, alongside underpinning technologies and infrastructure. Her role at CGTC Catapult also included advising academics and small companies on the development of advanced therapies. Prior to this, Terri held senior roles in industry focussed on the development of processes for the expansion and differentiation of pluripotent stem cells for therapeutic use and drug discovery. Terri received her BSc. (Hons) in Biochemistry from the University of Dundee and holds a PhD in Cell and Molecular Biology from the University of Edinburgh.

Dr. Faizah Mushtaq – Clinical Manager

Faizah is a clinically qualified audiologist who has previously provided hearing care to patients within both NHS and private settings. Subsequent completion of an MSc in Cognitive Neuroscience facilitated her transition from a clinician into a researcher and prepared her with the skills required to study for a doctorate (PhD) in translational hearing research. Faizah’s interests are embedded in research that addresses clinical needs, as demonstrated by her previous work, which aimed to develop an objective clinical measure of paediatric cochlear implant outcome which included a national multi-centre study involving cochlear implant recipients. At Rinri, Faizah focuses on working with our clinical partners to refine our clinical strategy, including the development of objective measures and surgical approach.

Doug Hartley

Doug HartleyDoug is a Professor of Otology at Nottingham University and a consultant ENT surgeon at Nottingham University Hospital’s NHS Trust – Queen’s Medical Centre. He qualified with distinction from Newcastle Medical School in 1995, and was awarded a DPhil from Oxford University in the field of hearing research in 2001. He worked as a Clinical Lecturer at Oxford University, and was the first recipient of a Wellcome Trust Clinician Scientist Fellowship in Otolaryngology. He spent time as a Surgical Fellow at the Sydney Cochlear Implant Centre, after becoming a Fellow of the Royal College of Surgeons, and completing his higher surgical training at the John Radcliffe Hospital in Oxford. Specializing in Otology, including cochlear implantation his research team at the NIHR Nottingham Hearing Biomedical Research Centre is interested in developing novel objective measures of hearing loss and communication impairments. He is also the lead surgeon for the Nottingham Auditory Implant Program and he serves on grant review panels for Action on Hearing loss and the NIHR.

Gerry O’Donoghue

Gerry O’DonoghueProfessor of Otology and Neurotology, University of Nottingham, Research Lead (Cochlear implantation). Gerry is the co-founder of the NIHR Nottingham Hearing BRU in 2008, is Honorary Professor of Otology and Neurotology at the University of Nottingham and Consultant Neuro-Otologist at Nottingham University Hospitals NHS Trust, Queen’s Medical Centre with special interests in cochlear implantation and skull base surgery.

Gerry is a Council Member of the British Association of Otolaryngologists and President-Elect of the Section of Otology, The Royal Society of Medicine, London. He has held a Hunterian Professorship at the Royal College of Surgeons of England and is founder member of the European Academy of Otology and Neurotology. He has delivered the Joseph Toynbee Memorial Lecture of the Royal Society of Medicine and was awarded an Honorary Professorship by the European Society of Paediatric Cochlear Implantation for outstanding contributions to the field.

Gerry’s principal interests lie in the field of cochlear implantation in children and adults. He has been involved in many outcomes studies and has written and lectured extensively in the field. He pioneered the development of minimally invasive surgery for paediatric cochlear implantation. Following the NICE approval of bilateral cochlear implantation for children, he has been actively involved in the national audit of the service. His work with the NIHR Nottingham Hearing BRU will involve a multicentre pilot study which sets out to determine whether adults with profound hearing loss in one ear (and normal hearing in the other) can derive benefit from cochlear implantation. His interests also extend to the field of skull base surgery where he is currently exploring the concept of computer-aided shared decision making in acoustic neuroma management.

Hubert Löwenheim

Hubert LöwenheimProf. Dr. med Hubert Löwenheim is Medical Director of the department of OHNS at the Tübingen University Medical Center and Principal Investigator of “Translational research Group”. Hubert studied human medicine at the Goethe University in Frankfurt am Main and Harvard University in Boston. After completing his doctorate in hearing research, also in Frankfurt, he continued his training as a specialist in Otolaryngology – Head & Neck Surgery and continued his scientific work at the University of Tübingen. After research stays at the University of Virginia in Charlottesville and the University of Washington in Seattle, he completed his habilitation at the University of Tübingen in the field of regenerative medicine of hearing. The focus of his clinical work lies in otology and neuro-otology including the supply of hearing implants and cochlear implants, oncological head and neck surgery and plastic reconstruction as well as interdisciplinary skull base surgery.

Dan Jiang

Dan JiangProfessor Dan Jiang is a well-respected Consultant ENT and Skull Base Surgeon. He has private practices at London Bridge Hospital, HCA UK at The Shard, The Harley Street Clinic, The Portland Hospital, The London Clinic and Westminster Bridge Consulting Rooms along with NHS bases at Guy’s and St Thomas’ Hospital, Evelina London Children Hospital and King’s College Hospital.

Dan has vast experience in all fields of adult and paediatric ENT and his clinical interests include ear surgery, hearing implants, deafness, dizziness and management of lateral skull base tumours. Dan was trained in Otolaryngology, Head and Neck Surgery at Guy’s and St. Thomas’ Hospital, King’s College Hospital and The National Hospital for Neurology and Neurosurgery (Queen Square).

The skilled surgeon completed a prestigious fellowship in Skull Base Surgery and Advanced Neuro-Otology at Addenbrooke’s Hospital, Cambridge. Dan was one of surgeons in Europe pioneered hearing preservation techniques in cochlear implant surgery, he was awarded a PhD following his research into auditory physiology and pathology. He remains involved in research in the field of auditory implants and regeneration of damaged inner ear structures at King’s College London. Dan is a board member of European Academy of Otology and Neurotology and a Trustee of British Cochlear Implant Group, he was ex Honorary Secretory and Vice President of Otology Section of the Royal Society of Medicine.

Unai Martinez de Estibariz

Unai Martinez de EstibarizUnai is a RCCP and BCIG registered an experienced audiologist. He is the Adult Auditory Implant Coordinator at The Richard Ramsden Centre for Hearing Implants in Manchester and BCIG Trustee with online media responsibilities. His clinical interests are in complex audiological rehabilitation, objective measurements, and candidacy selection in auditory implants.

Terry Nunn

Terry NunnTerry is a Consultant Clinical Audiologist at Guy’ and St Thomas NHS Trust. Terry began his career in 1988, employed by South west Thames Regional Health Authority. He trained within a variety of clinical areas which included, Audiology, Cardiology and Medical Physics. He joined Guy’ and St Thomas NHS Trust in 1993, completing an MSc in Technical Audiology in 2001. Following this, he was employed as a senior lecturer at UCL from 2004 to 2006, teaching clinical audiology. He has worked in the field of Auditory implantation for 17 years and his research and clinical interests include electrical neural coding and speech perception outcome measures. He was appointed as a Consultant Scientist and Head of Audiology in 2009.